hmoB [2017-8-11 16:0:3]

heme monooxygenase

locus: BSU10100

pI: 5.22

mw: 18.68 kDa

protein length: 166 aa

gene length: 498 bp

function: degradation of heme, acquisition of iron

product: heme monooxygenase

essential: no

synonyms: yixC, yhgC

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]

Gene

Coordinates: 1,083,229 → 1,083,729

The protein

Catalyzed reaction/ biological activity

• binds hemin ''in vitro'' with ~1:1 stoichiometry and degrade hemin in the presence of an electron donor [Pubmed|21873409]

Structure

• [PDB|3TVZ] [Pubmed|22531134]

Expression and Regulation

Operons

• genes: [gene|4EE1809AC405170A78F6F8C8C02EEF5CC54DE076|hmoB]
  description: [Pubmed|8335642]

  regulation

  • constitutively expressed [Pubmed|21873409]

Biological materials

Mutant

• MGNA-B503 (yhgC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1502 NBRP B. subtilis, Japan]

References

• 8335642,22531134,24582752,21873409